HyperQuant

Unique Benchtop NMR Reader to Quantify Hyperpolarization

HyperQuant TD-NMR System
HyperQuant TD-NMR System

HyperQuant is a benchtop time-domain NMR reader that precisely and quantitatively delivers both the magnetic hyperpolarization and thermal polarization status of a sample. This proprietary solution applies a unique
permanent 0.94 Tesla magnet system combined with an innovative MR probe
design and novel NMR pulse sequence capabilities. This unique combination
enables quantification of the thermal polarization level of 13C-labeled samples
using volumes as low as 1 ml. The hyperpolarization enhancement factors
can be obtained directly on the sample of interest, without the need for a separate calibration reference.
 

HyperQuantProduct Note0.2 MiB

Features

  • Direct quantification of magnetic hyperpolarization and thermal polarization levels
  • Calibration-free technology based on direct comparison of hyperpolarized and thermally polarized state
  • Turn-key 13C application
  • Proven benchtop TD-NMR design
  • Unique 0.94 T permanent magnet system
  • Only 1 ml of sample volume required
  • Tracing of the 13C hyperpolarization decay
  • Thermal signal determination with 99% accuracy
  • Quantifying concentrations of fully labeled 13C samples
  • External trigger interface to HyperSense®
  • Applicable to all hyperpolarization methods including DNP and Para-Hydrogen
     

Hyperpolarization & Enhancement Factor

Hyperpolarization vs. Thermal Polarization
Energy diagram for a spin 1/2 nuclei, like 13C, in a magnetic field: Hyperpolarization vs. (Boltzmann) thermal polarization.

Hyperpolarization promises to be a useful technique with its potential to boost contrast in MRI and sensitivity in solid-state NMR. Hyperpolarization provides a means to increase the nuclear magnetic polarisation by orders of magnitude (enhancement factors of 100,000) from the otherwise physical limit of the thermal Boltzmann polarization. Hyperpolarization can be obtained by various mechanisms, both physical and chemical in nature, such as DNP (dynamic nuclear polarization) and parahydrogen induced polarization (PHIP). Typically labeled 13C samples are utilized because of the preferential MR properties of the 13C nucleus.
  

Time-Domain NMR

Time-Domain NMR and Bruker's minispec series products are well known for its applicability in Quality Control (QC/QA) applications requiring precise and accurate determination of the quantity of interest, like oil and moisture in food.